gene expression in gastric carcinoma hpcaga（基因表达在胃癌hpcaga）.docVIP

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gene expression in gastric carcinoma hpcaga（基因表达在胃癌hpcaga）.doc

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gene expression in gastric carcinoma hpcaga（基因表达在胃癌hpcaga）

Gene expression in gastric carcinoma HpcagA Ming-De Jiang Chen Xiaobin Xu Hui: Yong Zeng Wei Zheng Chen Hongbin [Keywords] stomach tumor, Keywords: Helicobacter pylorus; cagA gene; stomach tumor Abstract: Objective the gastric the organization HpcagA gene infection, to explore the relationship between genes and gastric HpcagA Methods Warthin-Starry silver staining and in situ PCR method to detect chronic superficial gastritis (CSG35, cases of chronic atrophic gastritis (CAG40 cases and gastric cancer (CG35 gastric mucosa Hp and cagA gene infection. observed non-cancer patients with gastric mucosal inflammatory reaction result of chronic superficial gastritis, atrophic gastritis, cancer organizations, cancer adjacent gastric mucosa Hp detection rate of 57 %, 62%, 0% and 54%; cagA gene detection rate of 20%, 50%, 29% and 46%, respectively, atrophic gastritis, paracancer, group cagA gene detection rate was significantly higher than superficial gastritis (P lt;0.01. noncancerous patients with gastric mucosal single nuclear cells, leaf nuclear cell infiltration degree of cagA + group representing of cagA-group Hp + group compared with Hp-group significantly increased (P lt;0.01, and of cagA + group also compared with Hp + group was significantly increased ( P lt;0.05. conclusion atrophic gastritis, gastric cancer patients with cagA strain infection rate was significantly higher than that in chronic superficial gastritis group. cagA strains cause more severe inflammatory reaction. Description HpcagA strain infection and atrophic gastritis, gastric Off Shito close. Keywords: Helicobacter pylori; cagA gene; stomach neo-plasms Abstract: AIM To examine Helicobacter pylori (HpcagA gene infection in gastric cancer tissues so as to study the rela-tionship between Hp cagA gene and gastric cancer.METHODS Warthin-Starry silver staining was used to de-tect Hp, in situ polymerase chain reaction (PCRto detect Hp cagA gene infection in gastric mucosa from35cases