hawthorn extract on cardiac function in rats with heart failure impact analysis（山楂提取物在大鼠心脏功能与心力衰竭的影响分析）.docVIP

Hawthorn extract on cardiac function in rats with heart failure impact analysis [Abstract] Objective To study the hawthorn extract on doxorubicin-induced heart failure improved cardiac function role, and through the determination of cardiac NO, its mechanism. Method intraperitoneal injection of adriamycin rat model of heart failure copied. randomly divided into model group, control group, captopril, hawthorn water extract high, medium and low-dose group, 4 weeks after administration, measured left ventricular pressure, the maximum increase (decrease rate, myocardial NO content The results of water hawthorn extract can improve heart failure caused by left ventricular systolic pressure, the maximum increase (decrease rate of the absolute reduction (P lt;0.01, P lt;0.05, and can inhibit rat ventricular diastolic pressure increased (P lt;0.05 reduce the myocardial content of NO (P lt;0.01). Conclusion water extract of hawthorn can improve heart failure symptoms, its mechanism may be related to positive inotropic and anti-oxidation effects. [Keywords] water extract of hawthorn heart failure, cardiac function NO ventricular pressure Heart failure is also known as heart failure, is there enough in the case of venous blood back, because cardiac dysfunction, cardiac output can not meet the normal metabolism of blood diseases that require clinical cardiac commonly used, vasodilators, diuretics and neuroendocrine antagonists for treatment in recent years, Chinese medicine for heart failure clinical research has made great progress, a significant effect, and few side effects. medicine Shan Lihong Rosaceae Hawthorn from the dry ripe fruit, with blood circulation effect in recent years is also used in clinical heart failure, coronary heart disease and other diseases. In this study, hawthorn extract on doxorubicin-induced heart failure improved cardiac function SD rats the role of experimental research, by heart failure myocardial NO content, ventricular pressure and oth