腺病毒载体介导靶向bFGF地RNAi对体外培养前列腺间质细胞bFGF表达和其增殖和凋亡地影响.pdf

质bFGF的表达水平明显高于上皮组织，且间质中bFGF表达量的增加亦远高于上 皮组织。 前列腺间质细胞后，能够抑制其增殖，促进其凋亡，这些作用与其抑制了细胞bF6F 的表达有关。 关键词：bFGF RNAi腺病毒载体良性前列腺增生增殖凋亡 4 ● 英文论著摘要 ● TheEffectofAdenovirus--Dilivered shlL—kN Targeting bFGFontheProliferationand ofCultured Apoptosis ProstaticStroma Cells ective obj acommondiseaseinelder can Benignprostatichyperplasia(BPH)is men,which leadto lower tract anddoharmtotheheath complicatedurinary ofoldmen． symptoms Withthesocial andthe of isa developmentaging tendencypopulation，theresharp rateof BPH．Itcanbetreatedmedicationor increasingmobidity by bysurgery．The and former,including0【adrenergicreceptor 5tt-reducase not antagonists inhibitor，do showa thelatteristraumatic effect，while it’Seffective．Sowe satisfactory though shouldtofindothereffectiveandsafe totreatBPH． try way The tissueis of andstroma．Thearea prostatic composedepithelia stromaistwice as asthe areainnormal in ratioincreasesto5． large epithelia BPH，the prostate，while withthestroma the