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英文摘要
Effectsof onthe in
TopiramateHippocampalNeurogenesis
AdultRatsafterLithium inducedSeizures
Pilocarpine
ABSTRACT
recent that
Objective:Thestudydiscoveryneurogenesis
existsinthebrainofadultmammalsand zoneofthe
subgranular
dentate inthe isoneofthe zones.
gyrus hippocampus major
referstothe cells of
Neurogenesisprogenitorcapableproducing
new itincludesthe ofneural
cells,and
granule proliferation
cells、thesurvivalofnewborncells、theneuronal
progenitor
differentiationofnewborncellsandtheabnormal of
migration
newborn factorssuchasinjury、ischemia、
neurons.Many
anoxemiaand allleadtothe
epilepsy hippocampal
inadult isa clinical inthe
rats.Epilepsycomplicatedsyndrome
of repeatedly
departmentneurology,its
and treatment harmtothe
long-termdrug bringseverity patients
and isamedical case
society.Statusepilepticus emergency
becauseit is orcontinueseizure.Therecent
repeated
findthatstatus
experiments epilepsyimproves
the
of needthe
present,75percentepilepticpatients antiepileptic
tocontrolthe isoneofthe
drugs
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