consistent dissection of the protein interaction network by combining global and local metrics一致的蛋白质相互作用网络的解剖结合全球和本地度量.pdfVIP

Volume 8, Issue 12, Article R271Wanget al.2007 Open Access Method Consistent dissection of the protein interaction network by combining global and local metrics *† ‡ * * Chunlin Wang , Chris Ding , Qiaofeng Yang and Stephen R Holbrook Addresses: *Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. †Division of Infectious Diseases, School of Medicine, Stanford University, Stanford, CA 94035, USA. ‡Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Correspondence: Chunlin Wang. Email: wangcl@. Stephen R Holbrook. Email: SRHolbrook@ Published: 21 December 2007 Received: 22 June 2007 Revised: 14 December 2007 Genome 2007, 8:R271 (doi:10.1186/gb-2007-8-12-r271) Accepted: 21 December 2007 The electronic version of this article is the complete one and can be found online at /2007/8/12/R271 © 2008 Wang et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ules in the protein interaction network. /pIdentifying protein interaction modulespA new network decomposition method is proposed that uses both a global metric and a local metric to identify protein interaction mod- Abstract We propose a new network decomposition method to systematically identify p