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conserved features of cohesin binding along fission yeast chromosomes守恒的特性cohesin绑定的裂殖酵母染色体.pdf

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conserved features of cohesin binding along fission yeast chromosomes守恒的特性cohesin绑定的裂殖酵母染色体

Volume 10, Issue 5, Article R52et al.Schmidt2009 Open Access Research Conserved features of cohesin binding along fission yeast chromosomes Christine K Schmidt*‡, Neil Brookes†§ and Frank Uhlmann* Addresses: *Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, Lincolns Inn Fields, London WC2A 3PX, UK. †Bioinformatics and Biostatistics Service, Cancer Research UK London Research Institute, Lincolns Inn Fields, London WC2A 3PX, UK. ‡Current address: National Cancer Institute, NIH, Bethesda, MD 20892, USA. §Current address: Trinity Centre for High Performance Computing, Trinity College, Dublin 2, Ireland. Correspondence: Frank Uhlmann. Email: frank.uhlmann@.uk Published: 19 May 2009 Received: 6 December 2008 Revised: 6 March 2009 Genome Biology 2009, 10:R52 (doi:10.1186/gb-2009-10-5-r52) Accepted: 19 May 2009 The electronic version of this article is the complete one and can be found online at /2009/10/5/R52 © 2009 Schmidt et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. be organism-specific, come together to shape overall distribution./pCohesin bindingpHigh-resolution analysis of cohesin localization on fission yeast chromosomes reveals that several determinants, previously thought to Abstract Background: Cohesin holds sister chromatids together to enable their accurate segregation in mitosis. How, and where, cohesin binds to chromosomes