基质金属蛋白酶与骨关节炎（Matrix metalloproteinases and osteoarthritis）.docVIP

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基质金属蛋白酶与骨关节炎（Matrix metalloproteinases and osteoarthritis）.doc

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基质金属蛋白酶与骨关节炎（Matrix metalloproteinases and osteoarthritis）

基质金属蛋白酶与骨关节炎（Matrix metalloproteinases and osteoarthritis） Matrix metalloproteinases and osteoarthritis 2011-06-14 pipe Shi Guiying Osteoarthritis (osteoarthritis, OA) is the most common type of arthritis. Its pathological features include progressive degeneration and destruction of articular cartilage and osteophyte formation. Many years of studies have suggested that OA is related to trauma, inflammation, aging, metabolism and immunity, but the exact pathogenesis is still unknown. In recent years, it has been found that the imbalance of synthesis and degradation of extracellular matrix in OA articular cartilage is one of the important causes of cartilage degeneration. Among them, matrix metalloproteinases (MMPs) may play a decisive role. Therefore, in recent years, MMPs has become a hot spot in the study of OA pathogenesis. This article reviews the classification, regulation mechanism, biological function and the relationship between MMPs and OA. 1 MMPs classification and structure MMPs is a protease dependent superfamily of zinc ions. Depending on its substrate, MMPs can be divided into sub families such as collagenase (MMP-1, -8 and -13), (MMP-3, -7, -10 and -11) and gelatinase (MMP-2 and -9). In addition, the metal elastase (MMP-12) and membrane type I metalloproteinase (MMP-14) are other MMPs members [1]. Each of the amino acid sequences of MMP contains three determinants: propeptide, zinc ion and in vitro ligation. Among them, the propeptide determinant MMPs proenzyme was inactive, when it is activated by hydrolysis of zymogen; zinc ion determinant promoted the combination of enzyme and substrate; in addition to MMP-7, other MMPs at the carboxy terminus containing in vitro ligatin determinant, which determines the specificity of the enzyme substrate 2. Synthesis and activation of 2 MMPs zymogen MMPs in synthesis and enzyme gene transcription, three levels of plasminogen activation by cytokines, growth factors, hormones, drugs and tissue inhibitor of metallopr