a common cnr1 (cannabinoid receptor 1) haplotype attenuates the decrease in hdl cholesterol that typically accompanies weight gain共同cnr1(大麻素受体1)单体型变弱高密度脂蛋白胆固醇的降低,通常也伴随着体重增加.pdfVIP

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a common cnr1 (cannabinoid receptor 1) haplotype attenuates the decrease in hdl cholesterol that typically accompanies weight gain共同cnr1(大麻素受体1)单体型变弱高密度脂蛋白胆固醇的降低,通常也伴随着体重增加.pdf

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a common cnr1 (cannabinoid receptor 1) haplotype attenuates the decrease in hdl cholesterol that typically accompanies weight gain共同cnr1(大麻素受体1)单体型变弱高密度脂蛋白胆固醇的降低,通常也伴随着体重增加

A Common CNR1 (Cannabinoid Receptor 1) Haplotype Attenuates the Decrease in HDL Cholesterol That Typically Accompanies Weight Gain 1 2 3 4 4 Qiping Feng , Lan Jiang , Richard L. Berg , Melissa Antonik , Erin MacKinney , Jennifer Gunnell- 4 5 1 Santoro , Catherine A. McCarty , Russell A. Wilke * 1 Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 2 Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 3 Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America, 4 Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, 5 Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America Abstract We have previously shown that genetic variability in CNR1 is associated with low HDL dyslipidemia in a multigenerational obesity study cohort of Northern European descent (209 families, median = 10 individuals per pedigree). In order to assess the impact of CNR1 variability on the development of dyslipidemia in the community, we genotyped this locus in all subjects with class III obesity (body mass index .40 kg/m2) participating in a population-based biobank of similar ancestry. Twenty-two haplotype tagging SNPs, capturing the entire CNR1 gene locus plus 15 kb upstream and 5 kb downstream, were genotyped and tested for association with clinical lipid data. This biobank contains