a cortical attractor network with martinotti cells driven by facilitating synapses皮质吸引子网络martinotti细胞由促进突触.pdfVIP

A Cortical Attractor Network with Martinotti Cells Driven by Facilitating Synapses 1,3 2 1,3 Pradeep Krishnamurthy , Gilad Silberberg , Anders Lansner * 1 Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden, 2 Nobel Institute of Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden, 3 School of Computer Science and Communication, Department of Computational Biology, Royal Institute of Technology (KTH), Stockholm, Sweden Abstract The population of pyramidal cells significantly outnumbers the inhibitory interneurons in the neocortex, while at the same time the diversity of interneuron types is much more pronounced. One acknowledged key role of inhibition is to control the rate and patterning of pyramidal cell firing via negative feedback, but most likely the diversity of inhibitory pathways is matched by a corresponding diversity of functional roles. An important distinguishing feature of cortical interneurons is the variability of the short-term plasticity properties of synapses received from pyramidal cells. The Martinotti cell type has recently come under scrutiny due to the distinctly facilitating nature of the synapses they receive from pyramidal cells. This distinguishes these neurons from basket cells and other inhibitory interneurons typically targeted by depressing synapses. A key aspect of the work reported here has been to pinpoint the role of this variability. We first set out to reproduce quantitatively based on in vitro data the di-synaptic inhibitory microcircuit connecting two pyramidal cells via one or a few Martinotti cells. In a second step, we embedded this microcircuit in a previously d