原创力文档a determination of potential α-glucosidase inhibitors from azuki beans (vigna angularis)确定潜在α-glucosidase抑制剂红豆(豇豆属活动).pdfVIP
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a determination of potential α-glucosidase inhibitors from azuki beans (vigna angularis)确定潜在α-glucosidase抑制剂红豆(豇豆属活动)
Int. J. Mol. Sci. 2011, 12, 6445-6451; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
./journal/ijms
Article
A Determination of Potential α-Glucosidase Inhibitors from
Azuki Beans ( Vigna angularis)
Yang Yao, Xuzhen Cheng, Lixia Wang, Suhua Wang and Guixing Ren *
Institute of Crop Science, Chinese Academy of Agricultural Sciences, South Xueyuan Road,
Haidian District No.80, Beijing 100081, China; E-Mails: yaoyang@ (Y.Y.);
chengxz@ (X.C.);wanglx@ (L.W.); wangsh@ (S.W.);
* Author to whom correspondence should be addressed; E-Mail: renguixing@;
Tel.: +86-10-6211-5596; Fax: +86-10-6215-6596.
Received: 12 July 2011; in revised form: 1 September 2011 / Accepted: 21 September 2011 /
Published: 28 September 2011
Abstract: A 70% ethanol extract from azuki beans ( Vigna angularis) was extracted further
with CH Cl , EtOAc and n-BuOH to afford four fractions: CH Cl -soluble, EtOAc-soluble,
2 2 2 2
n-BuOH-soluble and residual extract fractions. The EtOAc-soluble fractions showed the
highest α-glucosidase inhibitory activity. Two pure flavonoid compounds, vitexin and
isovitexin, were isolated (using the enzyme assay-guide fractionation method)
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