a dominant, recombination-defective allele of dmc1 causing male-specific sterility主导,recombination-defective等位基因一代造成男性不育.pdfVIP

下载本文档

1
0
约8.52万字
约 10页
2017-09-07 发布于上海
举报
版权申诉

a dominant, recombination-defective allele of dmc1 causing male-specific sterility主导,recombination-defective等位基因一代造成男性不育.pdf

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

a dominant, recombination-defective allele of dmc1 causing male-specific sterility主导,recombination-defective等位基因一代造成男性不育

PLoS BIOLOGY A Dominant, Recombination-Defective Allele of Dmc1 Causing Male-Specific Sterility 1,2 3 3 4,5 1,2 Laura A. Bannister , Roberto J. Pezza , Janet R. Donaldson , Dirk G. de Rooij , Kerry J. Schimenti , R. Daniel Camerini-Otero3, John C. Schimenti1,2* 1 Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America, 2 The Jackson Laboratory, Bar Harbor, Maine, United States of America, 3 Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Department of Endocrinology, Utrecht University, Utrecht, The Netherlands, 5 Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands DMC1 is a meiosis-specific homolog of bacterial RecA and eukaryotic RAD51 that can catalyze homologous DNA strand invasion and D-loop formation in vitro. DMC1-deficient mice and yeast are sterile due to defective meiotic Mei11 recombination and chromosome synapsis. The authors identified a male dominant sterile allele of Dmc1, Dmc1 , encoding a missense mutation in the L2 DNA binding domain that abolishes strand invasion activity. Meiosis in male heterozygotes arrests in pachynema, characterized by incomplete chromosome synapsis and no crossing-over. Young heterozygous females have normal litter sizes despite having a decrease