a method to model season of birth as a surrogate environmental risk factor for disease方法模型的季节出生作为一个代理环境危险因素疾病.pdfVIP

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a method to model season of birth as a surrogate environmental risk factor for disease方法模型的季节出生作为一个代理环境危险因素疾病.pdf

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a method to model season of birth as a surrogate environmental risk factor for disease方法模型的季节出生作为一个代理环境危险因素疾病

Int. J. Environ. Res. Public Health 2008, 5(1), 49-53 International Journal of Environmental Research and Public Health ISSN 1661-7827 © 2008 by MDPI A Method to Model Season of Birth as a Surrogate Environmental Risk Factor for Disease Jimmy Thomas Efird1* and Susan Searles Nielsen2 1Cancer Research Center of Hawaii and John A. Burns School of Medicine, 651 Ilalo Street, Biosciences Bldg. 320-B, Honolulu, HI 96813, USA. 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Cancer Epidemiology Research Cooperative, POB 19024, 1100 Fairview Ave North, MS M4-C308, Seattle, WA 98109-1024 USA. *Correspondence to Dr. Jimmy Thomas Efird. E-mail: jimmy.efird@ Received: 9 September 2007 / Accepted: 29 February 2008 / Published: 30 March 2008 Abstract: Environmental exposures, including some that vary seasonally, may play a role in the development of many types of childhood diseases such as cancer. Those observed in children are unique in that the relevant period of exposure is inherently limited or perhaps even specific to a very short window during prenatal development or early infancy. As such, researchers have investigated whether specific childhood cancers are associated with season of birth. Typically a basic method for analysis