原创力文档a molecular epidemiological and genetic diversity study of tuberculosis in ibadan, nnewi and abuja, nigeria结核病分子流行病学和遗传多样性的研究在伊巴丹,这两名和尼日利亚阿布贾.pdfVIP
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a molecular epidemiological and genetic diversity study of tuberculosis in ibadan, nnewi and abuja, nigeria结核病分子流行病学和遗传多样性的研究在伊巴丹,这两名和尼日利亚阿布贾
A Molecular Epidemiological and Genetic Diversity Study
of Tuberculosis in Ibadan, Nnewi and Abuja, Nigeria
1 2 2 3 ´ 2
Lovett Lawson , Jian Zhang , Michel K. Gomgnimbou , Saddiq T. Abdurrahman , Stephanie Le Moullec ,
2 4 5 6 1
Fatima Mohamed , Gertrude N. Uzoewulu , Olumide M. Sogaolu , Khye Seng Goh , Nnamdi Emenyonu ,
´ 2 7 2
Guislaine Refregier , Luis E. Cuevas , Christophe Sola *
´ ´ ´
1 Zankli Medical Centre, Abuja, Nigeria, 2 Institut de Genetique et Microbiologie UMR8621, CNRS-Universite Paris-Sud, Orsay, France, 3 National Tuberculosis and Leprosy
Control Programme, Abuja, Nigeria, 4 Nnamdi Azikiwe Teaching Hospital, Nnewi, Nigeria, 5 University College Hospital, Ibadan, Nigeria, 6 Tuberculosis Laboratory
Consultant, Les Abymes, Guadeloupe, France, 7 Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Abstract
Background: Nigeria has the tenth highest burden of tuberculosis (TB) among the 22 TB high-burden countries in the
world. This study describes the biodiversity and epidemiology of drug-susceptible and drug-resistant TB in Ibadan, Nnewi
and Abuja, using 409 DNAs extracted from culture positive TB isolates.
Methodology/Principal Findings: DNAs extracted from clinical isolates of Mycobacterium tuberculosis complex were studied
by spoligotyping and 24 VNTR typing. The Cameroon clade (CAM) was predominant followed by the M. africanum (West
African 1) and T (mai
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