a quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes群体感应调节小的挥发性分子减少急性毒性和促进慢性感染表型.pdfVIP

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a quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes群体感应调节小的挥发性分子减少急性毒性和促进慢性感染表型.pdf

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a quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes群体感应调节小的挥发性分子减少急性毒性和促进慢性感染表型

A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes Meenu Kesarwani1,2¤a, Ronen Hazan1,2, Jianxin He1,2, YokAi Que1,2, Yiorgos Apidianakis 1,2, Biliana 1,2¤b 1,2 ´ 3 3 3 ´ 3 Lesic , Gaoping Xiao , Valerie Dekimpe , Sylvain Milot , Eric Deziel , Franc¸ois Lepine , Laurence G. Rahme1,2* 1 Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, 2 Shriners Burns Institute and ´ Massachusetts General Hospital, Boston, Massachusetts, United States of America, 3 INRS-Institut Armand-Frappier, Laval, Quebec, Canada Abstract A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial phenotypes controlled by complex regulatory networks that sense and respond to the host environment. Although bacterial signals that contribute to a successful acute infection have been identified in a number of pathogens, the signals that mediate the onset and establishment of chronic infections have yet to be discovered. We identified a volatile, low molecular weight molecule, 2-amino acetophenone (2-AA), produced by the opportunistic human pathogen Pseudomonas aeruginosa that reduces bacterial virulence in vivo in flies and in an acute mouse infection model. 2-AA modulates the activity of the virulence regulator MvfR (multiple virulence factor regulator) via a negative feedback loop and it promotes the emergen