a novel co-polymer based on hydroxypropyl α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector一种新颖的基于羟丙基丙烯α-cyclodextrin共轭低分子量表面进行体外基因传递载体.pdfVIP

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a novel co-polymer based on hydroxypropyl α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector一种新颖的基于羟丙基丙烯α-cyclodextrin共轭低分子量表面进行体外基因传递载体.pdf

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a novel co-polymer based on hydroxypropyl α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector一种新颖的基于羟丙基丙烯α-cyclodextrin共轭低分子量表面进行体外基因传递载体

Int. J. Mol. Sci. 2008, 9, 2278-2289; DOI: 10.3390/ijms9112278 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms/ Article A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector 1 2 2 2 2 3 Hongliang Huang , Hai Yu , Da Li , Yang Liu , Fenping Shen , Jun Zhou , Qingqing Wang 2,* and Guping Tang 3,* 1 School of Life Science, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, P. R. China. E-Mail: honglianghuangcn@ 2 Institute of Immunology, Zhejiang University, Yuhangtang Road 388, Hangzhou, P. R. China. E-Mails: yuhai@ (H. Y.); lidaonco@ (D. L.); liuyang1006@163.com (Y. L.); shenfenping@ (F. S.) 3 Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Tianmushan Road 148, Hangzhou, P. R. China. E-Mail: zerobomp@ (J. Z.) * Authors to whom correspondence should be addressed; E-Mail: tangguping@ (G. T.); Tel. +86-571-882-732-84; Fax: +86-571-882-732-84; E-Mail: wqq@ (Q. W.); Tel. +86-571-882-082-81 Received: 31 May 2008; in revised form: 4 November 2008 / Accepted: 7 November 2008 / Published: 21 November 2008 Abstract: A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The co- polymer