a review of keratin-based biomaterials for biomedical applications回顾keratin-based生物材料的生物医学应用.pdfVIP

Materials 2010, 3, 999-1014; doi:10.3390/ma3020999 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review A Review of Keratin-Based Biomaterials for Biomedical Applications Jillian G. Rouse and Mark E. Van Dyke * Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, North Carolina, USA; E-Mail: jrouse@ (J.G.R.) * Author to whom correspondence should be addressed; E-Mail: mavandyk@; Tel.: +1-336-713-7266; Fax: +1-336-713-7290. Received: 6 January 2009; in revised form: 24 January 2010 / Accepted: 26 January 2010 / Published: 3 February 2010 Abstract: Advances in the extraction, purification, and characterization of keratin proteins from hair and wool fibers over the past century have led to the development of a keratin- based biomaterials platform. Like many naturally-derived biomolecules, keratins have intrinsic biological activity and biocompatibility. In addition, extracted keratins are capable of forming self-assembled structures that regulate cellular recognition and behavior. These qualities have led to the development of keratin biomaterials with applications in wound healing, drug delivery, tissue engineering, trauma and medical devices. This review discusses the history of keratin research and the advancement of keratin biomaterials for biomedical applications. Keywords: keratin; human hair protein; natural biomaterial; protein film; scaffold 1. Introduction One of the primary goals of biomaterials research i