原创力文档a2br adenosine receptor modulates sweet taste in circumvallate taste budsa2br腺苷受体调节用城墙围住的甜味的味蕾.pdfVIP
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a2br adenosine receptor modulates sweet taste in circumvallate taste budsa2br腺苷受体调节用城墙围住的甜味的味蕾
A2BR Adenosine Receptor Modulates Sweet Taste in
Circumvallate Taste Buds
Shinji Kataoka1,2.¤a, Arian Baquero1,3.¤b, Dan Yang4¤c, Nicole Shultz1,2, Aurelie Vandenbeuch1,3, Katya
Ravid4, Sue C. Kinnamon1,3, Thomas E. Finger1,2*
1 Rocky Mountain Taste Smell Center, University of Colorado School of Medicine, Aurora, Colorado, United States of America, 2 Department of Cell Developmental
Biology, University of Colorado School of Medicine, Aurora, Colorado, United States of America, 3 Depatment of Otolaryngology, University of Colorado School of
Medicine, Aurora, Colorado, United States of America, 4 Departments of Medicine and Biochemistry and Whitaker Cardiovascular Institute, Boston University School of
Medicine, Boston, Massachusetts, United States of America
Abstract
In response to taste stimulation, taste buds release ATP, which activates ionotropic ATP receptors (P2X2/P2X3) on taste
nerves as well as metabotropic (P2Y) purinergic receptors on taste bud cells. The action of the extracellular ATP is
terminated by ectonucleotidases, ultimately generating adenosine, which itself can activate one or more G-protein coupled
adenosine receptors: A1, A2A, A2B, and A3. Here we investigated the expression of adenosine receptors in mouse taste
buds at both the nucleotide and protein expression levels. Of the adenosine receptors, only A2B receptor (A2BR) is
expressed specifically in taste epithelia. Further, A2BR is expressed abundantly only in a subset of taste bud cells of posterior
(circumvallate, foliate), but not anterior (fungiform, palate) taste fields in mice. Analysis of double-labeled tissue indicates
that A2BR occurs on Type II taste bud cells that also express Ga14, which is present only in sweet-sensitive taste cells of the
foliate and circumvallate papillae. Glossopharyngeal nerve recordings from A2BR knocko
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