小剂量多次注射可增强艾塞那肽对2型糖尿病的治疗效果.docVIP

DOI：10.16016/j.1000-5404.201501192 小剂量多次注射艾塞那肽2型糖尿病 江雪舒，肖惟引，谭明红，魏平（（400038重庆，第三军医大学西南医院内分泌科） 摘要目的探讨艾塞那肽2型糖尿病的疗效及安全性。方法 选择2型糖尿病23例，随机分为艾塞那肽2针治疗组12例，3针治疗组11例，比较治疗前后6个月体质量、BMI、腰围、腰臀比、空腹血糖（FPG）、餐后2血糖（2hPG）、糖化血红蛋白（HbA1C）、空腹及餐后C肽、自我血糖监测（SMBG）、总胆固醇（Tch）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（LDL-C）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、血肌酐（Cr）、尿素氮（UN）。结果两组体质量、腰围、腰臀比、FPG、PPG、HbA1C、Tch、TG、LDL-C、HDL-C均较治疗前有所下降，组间比较差异无统计学意义（P＞0.05），两组患者治疗后BMI较治疗前明显下降，其中3针组患者BMI下降较2针组明显（P＜0.05），两组患者治疗后SMBG均较治疗前明显下降，3针组患者午餐后血糖及睡前血糖较2针组更低（P＜0.05）。结论 μg艾塞那肽更有利于2型糖尿病餐后血糖的控制。[关键词] 艾塞那肽血糖糖尿病 [] R697+.33；R331 [文献标志码] A Multiple small-dose injection enhances therapeutic effect of exenatide on type 2 diabetes mellitus Jiang Xueshu, Xiao Weiyin, Tan Minghong, Wei Ping (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China) [Abstract] Objective To investigate the efficacy and safety of multiple small does injection of exenatide in the treatment of type 2 diabetes mellitus. Methods A prospective study was performed on 23 patients with type 2 diabetes hospitalized in our department from January to June 2014. They were 12 males and 11 females, at an average age of 49.2 years. The cohort was randomized into control (n=12) and observation group (n=11). Beside their original regimen of hypoglycemic agents, they were injected with 5 μg exenatide once per day for 1 week, and then the former group was given 10 μg twice per day while the latter 5 μg 3 times per day for 6 consecutive months. Body weight, BMI, waist circumference, waist to hip ratio, fasting blood glucose (FPG), 2 hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1C), fasting and 2 hour postprandial C peptide, self monitored fasting and postprandial blood glucose (SMBG), total cholesterol (Tch), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creati