rapid antigen detection tests for malaria diagnosis in severely ill papua new guinean children a comparative study using bayesian latent class models快速抗原检测测试疟疾诊断重症巴布新几内亚的孩子比较研究使用贝叶斯潜在的类模型.pdfVIP

Rapid Antigen Detection Tests for Malaria Diagnosis in Severely Ill Papua New Guinean Children: A Comparative Study Using Bayesian Latent Class Models 1 1,2. 2 3 2 2 Laurens Manning , Moses Laman , Anna Rosanas-Urgell , Berwin Turlach , Susan Aipit , Cathy Bona , 2 2 2,4,5. 1 . Jonathan Warrell , Peter Siba , Ivo Mueller , Timothy M. E. Davis * 1 School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia, 2 Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea, 3 Centre for Applied Statistics, University of Western Australia, Crawley, Western Australia, Australia, 4 Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain, 5 Walter and Eliza Hall Institute, Parkville, Melbourne, Australia Abstract Background: Although rapid diagnostic tests (RDTs) have practical advantages over light microscopy (LM) and good sensitivity in severe falciparum malaria in Africa, their utility where severe non-falciparum malaria occurs is unknown. LM, RDTs and polymerase chain reaction (PCR)-based methods have limitations, and thus conventional comparative malaria diagnostic studies employ imperfect gold standards. We assessed whether, using Bayesian latent class models (LCMs) which do not require a reference method, RDTs could safely direct initial anti-infective therapy in severe ill children from an area of hyperendemic transmission of both Plasmodium falciparum and P. vivax. Methods and Findings: We studied 797 Papua New Guinean children hospitalized with well-characterized severe illn