rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strengthrapid-throughput骨骼100基因敲除小鼠的表型出现标识确定骨骼强度9新基因.pdfVIP

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength 1. 1 2 3 4 J. H. Duncan Bassett , Apostolos Gogakos , Jacqueline K. White , Holly Evans , Richard M. Jacques , 1 2 2 Anne H. van der Spek , Sanger Mouse Genetics Project, Ramiro Ramirez-Solis , Edward Ryder , 2 5 4 3,6 . * 1. * David Sunter , Alan Boyde , Michael J. Campbell , Peter I. Croucher , Graham R. Williams 1 Molecular Endocrinology Group, Department of Medicine, Imperial College London, London, United Kingdom, 2 Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, 3 The Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom, 4 School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, 5 Queen Mary University of London, Oral Growth and Development, Institute of Dentistry, Bart’s and The London School of Medicine, London, United Kingdom, 6 Garvan Institute of Medical Research, Sydney, Australia Abstract Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice generated by the Wellcome Trust Sanger Instit