reduced susceptibility of dna methyltransferase 1 hypomorphic (dnmt1n+) mice to hepatic steatosis upon feeding liquid alcohol diet敏感性降低dna甲基转移酶1 hypomorphic(dnmt1n +)小鼠肝脂肪变性在喂养液体酒精饮食.pdfVIP

下载本文档

5
0
约8.73万字
约 14页
2017-09-09 发布于上海
举报
版权申诉

reduced susceptibility of dna methyltransferase 1 hypomorphic (dnmt1n+) mice to hepatic steatosis upon feeding liquid alcohol diet敏感性降低dna甲基转移酶1 hypomorphic(dnmt1n +)小鼠肝脂肪变性在喂养液体酒精饮食.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

reducedsusceptibilityofdnamethyltransferase1hypomorphic(dnmt1n)micetohepaticsteatosisuponfeedingliquidalcoholdiet敏感性降低dna甲基转移酶1hypomorphic(dnmt1n)小鼠肝脂肪变性在喂养液体酒精饮食

Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to Hepatic Steatosis upon Feeding Liquid Alcohol Diet 1. 2. 1,2,3. 1,2,3. 2. 4 Huban Kutay , Corie Klepper , Bo Wang , Shu-hao Hsu , Jharna Datta , Lianbo Yu , 4 1 1 2 5 6 Xiaoli Zhang , Sarmila Majumder , Tasneem Motiwala , Nuzhat Khan , Martha Belury , Craig McClain , Samson Jacob1,2,7*, Kalpana Ghoshal1,7,8* 1 Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 2 Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 3 Molecular, Cellular and Developmental Biology Program, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 4 Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 5 Department of Nutrition, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 6 Department of Medicine, University of Louisville and the Robley Rex Louisville VAMC, Louisville, Kentucky, United States of America, 7 Experimental Therapeutics Program, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, 8 Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America Abstract Background: Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). A