原创力文档reduced t2 values in soleus muscle of patients with type 2 diabetes mellitus比目鱼肌的t2值降低2型糖尿病患者.pdfVIP
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reduced t2 values in soleus muscle of patients with type 2 diabetes mellitus比目鱼肌的t2值降低2型糖尿病患者
Reduced T2* Values in Soleus Muscle of Patients with
Type 2 Diabetes Mellitus
1 1 2 1 3 1
Chun S. Zuo *, Young-Hoon Sung , Donald C. Simonson , Erin Habecker , Jian Wang *, Charlotte Haws ,
1 1 4 4 4
Rosemond A. Villafuerte , Michael E. Henry , Robert L. Dobbins , Rebecca J. Hodge , Derek J. R. Nunez ,
Perry F. Renshaw1
1 Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America, 2 Brigham and Women’s Hospital, Harvard Medical
School, Boston, Massachusetts, United States of America, 3 Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China,
4 GlaxoSmithKline, Research and Development, Research Triangle Park, North Carolina, United States of America
Abstract
Tissue water transverse relaxation times (T2) are highly sensitive to fluid and lipid accumulations in skeletal muscles whereas
the related T2* is sensitive to changes in tissue oxygenation in addition to factors affecting T2. Diabetes mellitus (DM)
affects muscles of lower extremities progressively by impairing blood flow at the macrovascular and microvascular levels.
This study is to investigate whether T2 and T2* are sensitive enough to detect abnormalities in skeletal muscles of diabetic
patients in the resting state. T2 and T2* values in calf muscle of 18 patients with type 2 DM (T2DM), 22 young healthy
controls (YHC), and 7 age-matched older healthy controls (OHC) were measured at 3T using multi-TE spin echo and gradient
echo sequences. Regional lipid levels of the soleus muscle were also measured using the Dixon
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