原创力文档rapid turnover of 2-ltr hiv-1 dna during early stage of highly active antiretroviral therapy快速周转2-ltr hiv - 1基因在早期阶段的高活性抗逆转录病毒疗法.pdfVIP
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rapid turnover of 2-ltr hiv-1 dna during early stage of highly active antiretroviral therapy快速周转2-ltr hiv - 1基因在早期阶段的高活性抗逆转录病毒疗法
Rapid Turnover of 2-LTR HIV-1 DNA during Early Stage of
Highly Active Antiretroviral Therapy
1. 2. 1 2 2 2 2 2
Weijun Zhu , Yanmei Jiao , Rongyue Lei , Wei Hua , Rui Wang , Yunxia Ji , Zhiying Liu , Feili Wei ,
2 3 2 1,3
Tong Zhang , Xuanlin Shi , Hao Wu *, Linqi Zhang *
1 AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2 Center for Infectious
Diseases, Beijing You-An Hospital, Capital Medical University, Beijing, China, 3 Comprehensive AIDS Research Center and Research Center for Public Health, School of
Medicine, Tsinghua University, Beijing, China
Abstract
Background: Despite prolonged treatment with highly active antiretroviral therapy (HAART), the infectious HIV-1 continues
to replicate and resides latently in the resting memory CD4+ T lymphocytes, which blocks the eradication of HIV-1. The viral
persistence of HIV-1 is mainly caused by its proviral DNA being either linear nonintegrated, circular nonintegrated, or
integrated. Previous reports have largely focused on the dynamics of HIV-1 DNA from the samples collected with relatively
long time intervals during the process of disease and HAART treatment, which may have missed the intricate changes
during the intervals in early treatment.
Methodology/Principal Findings: In this study, we investigated the dynamics of HIV-1 DNA in patients during the early
phase of HARRT treatment. Using optimized real time PCR, we observed significant change
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