role of serotonin via 5-ht2b receptors in the reinforcing effects of mdma in mice通过5-ht2b 5 -羟色胺受体的作用强化mdma在小鼠的影响.pdfVIP

Role of Serotonin via 5-HT2B Receptors in the Reinforcing Effects of MDMA in Mice ´ 1,2 1,2 3,4 1,2 Stephane Doly , Jesus Bertran-Gonzalez , Jacques Callebert , Alexandra Bruneau , Sophie Marie 1,2 1,2 1,2 ´ 1,2 3,4 Banas , Arnauld Belmer , Katia Boutourlinsky , Denis Herve , Jean-Marie Launay , Luc Maroteaux1,2* ´ ` ˆ ` 1 INSERM U839, Paris, France, 2 Universite Pierre et Marie Curie, Paris 6, Institut du Fer a Moulin, UMR-S0839, Paris, France, 3 AP-HP, Hopital Lariboisiere, Service de Biochimie, Paris, France, 4 INSERM U942, Paris, France Abstract The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the role of serotonin/dopamine interactions in the behavioral effects of MDMA remains unclear. We previously showed that MDMA-induced locomotion, serotonin and dopamine release are 5-HT2B receptor-dependent. The aim of the present study was to determine the contribution of serotonin and 5-HT2B receptors to the reinforcing properties of MDMA. We show here that 5-HT2B2/ 2 mice do not exhibit behavioral sensitization or conditioned place preference following MDMA (10 mg/kg) injections. In addition, MDMA-induced reinstatement