原创力文档sensitive detection of chromosomal segments of distinct ancestry in admixed populations敏感的检测染色体段不同血统的混血人口.pdfVIP
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sensitive detection of chromosomal segments of distinct ancestry in admixed populations敏感的检测染色体段不同血统的混血人口
Sensitive Detection of Chromosomal Segments of
Distinct Ancestry in Admixed Populations
1,2,3 3,4 3 5 5
Alkes L. Price , Arti Tandon , Nick Patterson , Kathleen C. Barnes , Nicholas Rafaels , Ingo
6 6 7 3,4 3,8,9
Ruczinski , Terri H. Beaty , Rasika Mathias , David Reich *, Simon Myers *
1 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Department of Biostatistics, Harvard School of Public
Health, Boston, Massachusetts, United States of America, 3 Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, 4 Department of
Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Johns Hopkins Allergy and Asthma Center, Division of Clinical Immunology,
Department of Medicine, School of Medicine, Baltimore, Maryland, United States of America, 6 Department of Biostatistics, Johns Hopkins School of Public Health,
Baltimore, Maryland, United States of America, 7 Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore,
Maryland, United States of America, 8 Department of Statistics, Oxford University, Oxford, United Kingdom, 9 Wellcome Trust Centre for Human Genetics, University of
Oxford, Oxford, United Kingdom
Abstract
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease
mapping to learning about history. Most methods require the use of unlinked markers; but, using all markers from genome-
wide scanning arrays, it should in principl
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