sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol contentlysosome-dependent敏感性细胞死亡是直接由溶酶体的胆固醇含量.pdfVIP

Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content 1 1 ¨ ¨ 2,3 4 5,6 ¨ 1,7 Hanna Appelqvist *, Linnea Sandin , Karin Bjornstrom , Paul Saftig , Brett Garner , Karin Ollinger , ˚ 1 Katarina Kagedal ¨ ¨ 1 Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden, 2 Anaesthesiology, ¨ ¨ Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden, 3 Department of Anaesthesiology UHL, County Council ¨ ¨ ¨ of Ostergotland, Linkoping, Sweden, 4 Biochemical Institute, Christian-Albrechts-University Kiel, Kiel, Germany, 5 Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia, 6 School of Biological Sciences, University of Wollongong, Wollongong, Australia, 7 Department of Clinical Pathology and Clinical ¨ ¨ ¨ Genetics, County Council of Ostergotland, Linkoping, Sweden Abstract Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type C1