sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial trnatyr gene金毛猎犬狗感觉混乱的神经病变是由线粒体trnatyr基因的缺失造成的.pdfVIP

Sensory Ataxic Neuropathy in Golden Retriever Dogs Is Caused by a Deletion in the Mitochondrial tRNATyr Gene 1 ¨ 2,3 4 5 5 Izabella Baranowska , Karin Hultin Jaderlund , Inger Nennesmo , Erik Holmqvist , Nadja Heidrich , ¨ 4 ¨ 1 5 ˚ 2 4 Nils-Goran Larsson , Goran Andersson , E. Gerhart H. Wagner , Ake Hedhammar , Rolf Wibom , Leif Andersson1,6* 1 Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden, 2 Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden, 3 Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway, 4 Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, 5 Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden, 6 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden Abstract Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers. Pedigree analysis revealed that all affected dogs belong to one maternal lineage, and a statistical analysis showed that the disorder has a mitochondrial origin. A one base pair deletion in the mitochondrial tRNATyr gene was identified at position 5304 in affected dogs after re-sequencing the complete mitochondrial genome of seven individuals. The deletion was