原创力文档sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor sdf-1 following myocardial ischemiareperfusion本来+心脏干细胞调解急性心脏保护通过旁分泌因子sdf-1后心肌ischemiareperfusion.pdfVIP
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sca-1cardiacstemcellsmediateacutecardioprotectionviaparacrinefactorsdf-1followingmyocardialischemiareperfusion本来心脏干细胞调解急性心脏保护通过旁分泌因子sdf-1后心肌ischemiareperfusion
Sca-1+ Cardiac Stem Cells Mediate Acute
Cardioprotection via Paracrine Factor SDF-1 following
Myocardial Ischemia/Reperfusion
1 1 2,3 1 1 1
Chunyan Huang , Hongmei Gu , Qing Yu , Mariuxi C. Manukyan , Jeffrey A. Poynter , Meijing Wang *
1 Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 2 Department of Pediatrics, Indiana University School of
Medicine, Indianapolis, Indiana, United States of America, 3 Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana,
United States of America
Abstract
Background: Cardiac stem cells (CSCs) promote myocardial recovery following ischemia through their regenerative
properties. However, little is known regarding the implication of paracrine action by CSCs in the setting of myocardial
ischemia/reperfusion (I/R) injury although it is well documented that non-cardiac stem cells mediate cardioprotection via
the production of paracrine protective factors. Here, we studied whether CSCs could initiate acute protection following
global myocardial I/R via paracrine effect and what component from CSCs is critical to this protection.
Methodology/Principal Findings: A murine model of global myocardial I/R was utilized to investigate paracrine effect of
Sca-1+ CSCs on cardiac function. Intracoronary delivery of CSCs or CSC conditioned medium (CSC CM) prior to ischemia
significantly improved myocardial function following I/R. siRNA targeting of VEGF in CSCs did not affect CSC-preserved
myocardial function in response to I/R injury. However, differentiation of CSCs to cardiomyocytes (DCSCs) abolished this
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