原创力文档schistosoma haematobium treatment in 1–5 year old children safety and efficacy of the antihelminthic drug praziquantel埃及血吸虫治疗1 - 5岁儿童antihelminthic药物吡喹酮的安全性和有效性.pdfVIP
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schistosoma haematobium treatment in 1–5 year old children safety and efficacy of the antihelminthic drug praziquantel埃及血吸虫治疗1 - 5岁儿童antihelminthic药物吡喹酮的安全性和有效性
Schistosoma haematobium Treatment in 1–5 Year Old
Children: Safety and Efficacy of the Antihelminthic Drug
Praziquantel
1 1 1 1¤a 1 1
Francisca Mutapi *, Nadine Rujeni , Claire Bourke , Kate Mitchell , Laura Appleby , Norman Nausch ,
Nicholas Midzi2, Takafira Mduluza3¤b
1 Ashworth Laboratories, Institute of Immunology Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2 National
Institute of Health Research, Causeway, Harare, Zimbabwe, 3 Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe
Abstract
Background: Morbidity due to schistosomiasis is currently controlled by treatment of schistosome infected people with the
antihelminthic drug praziquantel (PZQ). Children aged up to 5 years are currently excluded from schistosome control
programmes largely due to the lack of PZQ safety data in this age group. This study investigated the safety and efficacy of
PZQ treatment in such children.
Methods: Zimbabwean children aged 1–5 years (n = 104) were treated with PZQ tablets and side effects were assessed by
questionnaire administered to their caregivers within 24 hours of taking PZQ. Treatment efficacy was determined 6 weeks
after PZQ administration through schistosome egg counts in urine. The change in infection levels in the children 1–5 years
old (n = 100) was compared to that in 6–10 year old children (n = 435).
Principal Findings: Pre-treatment S. haematobium infection intensity in 1–5 year olds was 14.6 eggs/10 ml urine and
prevalence was 21%. Of the 104 children, 3.8% reported side effects within 24 hours of taking PZQ treatment. These were
stomach ache, loss of appet
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