sensory coding by cerebellar mossy fibres through inhibition-driven phase resetting and synchronisation感觉编码通过小脑苔藓纤维inhibition-driven阶段重置和同步.pdfVIP

Sensory Coding by Cerebellar Mossy Fibres through Inhibition-Driven Phase Resetting and Synchronisation 1 ¨ 2 Tahl Holtzman *, Henrik Jorntell 1 Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom, 2 Section for Neurophysiology and Neuronano Research Center, Lund, Sweden Abstract Temporal coding of spike-times using oscillatory mechanisms allied to spike-time dependent plasticity could represent a powerful mechanism for neuronal communication. However, it is unclear how temporal coding is constructed at the single neuronal level. Here we investigate a novel class of highly regular, metronome-like neurones in the rat brainstem which form a major source of cerebellar afferents. Stimulation of sensory inputs evoked brief periods of inhibition that interrupted the regular firing of these cells leading to phase-shifted spike-time advancements and delays. Alongside phase-shifting, metronome cells also behaved as band-pass filters during rhythmic sensory stimulation, with maximal spike-stimulus synchronisation at frequencies close to the idiosyncratic firing frequency of each neurone. Phase-shifting and band-pass filtering serve to temporally align ensembles of metronome cells, leading to sustained volleys of near-coincident spike- times, thereby transmitting synchronised sensory information to downstream targets in the cerebellar cortex. ¨ Citation: Holtzman T, Jorntell H (2011) Sensory Coding by Cerebellar Mossy Fibres through Inhibition-Driven Phase Resetting and Synchronisation. PLoS ONE 6(10): e26503. doi:10.1371/journal.pone.0026503 Editor: Izumi Sugihara, Tokyo Medical and Dental University, Japan Received May 24, 2011; Accepted September 28