原创力文档sequence diversity within the capsular genes of streptococcus pneumoniae serogroup 6 and 19肺炎链球菌荚膜基因的序列多样性血清组6 - 19所示.pdfVIP
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sequence diversity within the capsular genes of streptococcus pneumoniae serogroup 6 and 19肺炎链球菌荚膜基因的序列多样性血清组6 - 19所示
Sequence Diversity within the Capsular Genes of
Streptococcus pneumoniae Serogroup 6 and 19
1 1 1 1 1
Karin Elberse *, Sandra Witteveen , Han van der Heide , Ingrid van de Pol , Corrie Schot , Arie van der
2 1 1
Ende , Guy Berbers , Leo Schouls
1 Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 2 The
Netherlands Reference Laboratory for Bacterial Meningitis and Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
Abstract
The main virulence factor of Streptococcus pneumoniae is the capsule. The polysaccharides comprising this capsule are
encoded by approximately 15 genes and differences in these genes result in different serotypes. The aim of this study was
to investigate the sequence diversity of the capsular genes of serotypes 6A, 6B, 6C, 19A and 19F and to explore a possible
effect of vaccination on variation and distribution of these serotypes in the Netherlands. The complete capsular gene locus
was sequenced for 25 serogroup 6 and for 20 serogroup 19 isolates. If one or more genes varied in 10 or more base pairs
from the reference sequence, it was designated as a capsular subtype. Allele-specific PCRs and specific gene sequencing of
highly variable capsular genes were performed on 184 serogroup 6 and 195 serogroup 19 isolates to identify capsular
subtypes. This revealed the presence of 6, 3 and a single capsular subtype within serotypes 6A, 6B and 6C, respectively. The
serotype 19A and 19F isolates comprised 3 and 4 capsular subtypes, respectively. For serogroup 6, the genetic background,
as determined by multi
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