sequences from first settlers reveal rapid evolution in icelandic mtdna pool序列从第一定居者揭示快速进化的冰岛mtdna池.pdfVIP

sequences from first settlers reveal rapid evolution in icelandic mtdna pool序列从第一定居者揭示快速进化的冰岛mtdna池.pdf

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sequences from first settlers reveal rapid evolution in icelandic mtdna pool序列从第一定居者揭示快速进化的冰岛mtdna池

Sequences From First Settlers Reveal Rapid Evolution in Icelandic mtDNA Pool 1,2 3 1 ´ ´ 1 Agnar Helgason *, Carles Lalueza-Fox , Shyamali Ghosh , Sigrun Sigurðardottir , Maria Lourdes 3,4 3 1 3 ´ ´ 5 1,6 Sampietro , Elena Gigli , Adam Baker , Jaume Bertranpetit , Lilja Arnadottir , Unnur Þorsteinsdottir , ´ ´ 1,6 Kari Stefansson 1 deCODE Genetics, Reykjavik, Iceland, 2 Department of Anthropology, University of Iceland, Reykjavik, Iceland, 3 Institute of Evolutionary Biology (UPF-CSIC), Barcelona, Spain, 4 Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands, 5 National Museum of Iceland, Reykjavik, Iceland, 6 Faculty of Medicine, University of Iceland, Reykjavik, Iceland Abstract A major task in human genetics is to understand the nature of the evolutionary processes that have shaped the gene pools of contemporary populations. Ancient DNA studies have great potential to shed light on the evolution of populations because they provide the opportunity to sample from the same population at different points in time. Here, we show that a sample of mitochondrial DNA (mtDNA) control region sequences from 68 early medieval Icelandic skeletal remains is more closely related to sequences from contemporary inhabitants of Scotland, Ireland, and Scandinavia than to those from the modern Icelandic population. Due to a faster rate of genetic drift in the Icelandic mtDNA pool during the last 1,100 years, the sequences carried by the first settlers were better preserved in their ancestral gene po

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