原创力文档sequence-based polymorphisms in the mitochondrial d-loop and potential snp predictors for chronic dialysis在线粒体d-loop和潜在的snp序列多态性预测慢性透析.pdfVIP
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sequence-based polymorphisms in the mitochondrial d-loop and potential snp predictors for chronic dialysis在线粒体d-loop和潜在的snp序列多态性预测慢性透析
Sequence-Based Polymorphisms in the Mitochondrial D-
Loop and Potential SNP Predictors for Chronic Dialysis
1 2 1 3 3 4
Jin-Bor Chen , Yi-Hsin Yang , Wen-Chin Lee , Chia-Wei Liou , Tsu-Kung Lin , Yueh-Hua Chung , Li-
5 6 7,8
Yeh Chuang , Cheng-Hong Yang *, Hsueh-Wei Chang *
1 Division of Nephrology, Department of Internal Medicine, Mitochondrial Research Unit, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of
Medicine, Kaohsiung, Taiwan, 2 School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, 3 Department of Neurology and Mitochondrial Research Unit,
Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 4 Institute of Biomedical Sciences, National Sun Yat-Sen
University, Kaohsiung, Taiwan, 5 Department of Chemical Engineering Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan,
6 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan, 7 Department of Biomedical Science and Environmental
Biology, Kaohsiung Medical University, Taiwan, 8 Center of Excellence for Environmental Medicine, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung
Medical University, Kaohsiung, Taiwan
Abstract
Background: The mitochondrial (mt) displacement loop (D-loop) is known to accumulate structural alterations and
mutations. The aim of this study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) within the D-
loop among chronic dialysis patients and healthy controls.
Methodology an
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