原创力文档sex-specific immunization for sexually transmitted infections such as human papillomavirus insights from mathematical models性别为性传播传染病,如人类乳头状瘤病毒疫苗接种的见解从数学模型.pdfVIP
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sex-specific immunization for sexually transmitted infections such as human papillomavirus insights from mathematical models性别为性传播传染病,如人类乳头状瘤病毒疫苗接种的见解从数学模型
Sex-Specific Immunization for Sexually Transmitted
Infections Such as Human Papillomavirus: Insights from
Mathematical Models
1,2 2,3 2 4
Johannes A. Bogaards *, Mirjam Kretzschmar , Maria Xiridou , Chris J. L. M. Meijer , Johannes
Berkhof1, Jacco Wallinga2,3
1 Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands, 2 Centre for Infectious Disease Control, National Institute for
Public Health and the Environment, Bilthoven, The Netherlands, 3 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The
Netherlands, 4 Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Abstract
Background: Sex-specific differences regarding the transmissibility and the course of infection are the rule rather than the
exception in the epidemiology of sexually transmitted infections (STIs). Human papillomavirus (HPV) provides an example:
disease outcomes differ between men and women, as does the potential for transmission to the opposite sex. HPV
vaccination of preadolescent girls was recently introduced in many countries, and inclusion of boys in the vaccination
programs is being discussed. Here, we address the question of whether vaccinating females only, males only, or both sexes
is the most effective strategy to reduce the population prevalence of an STI like HPV.
Methods and Findings: We use a range of two-sex transmission models with varying detail to identify general criteria for
allocating a prophylactic vaccine between both sexes. The most effective reduction in the population prevalence of
infection is always achieved by single-sex vaccination; vaccinating the sex with the highest prevacc
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