sexual behaviour and hpv infections in 18 to 29 year old women in the pre-vaccine era in the netherlands性行为和人乳头状瘤病毒感染在18至29岁的女性在荷兰使用疫苗前的时代.pdfVIP

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2017-09-09 发布于上海
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sexual behaviour and hpv infections in 18 to 29 year old women in the pre-vaccine era in the netherlands性行为和人乳头状瘤病毒感染在18至29岁的女性在荷兰使用疫苗前的时代.pdf

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sexual behaviour and hpv infections in 18 to 29 year old women in the pre-vaccine era in the netherlands性行为和人乳头状瘤病毒感染在18至29岁的女性在荷兰使用疫苗前的时代

Sexual Behaviour and HPV Infections in 18 to 29 Year Old Women in the Pre-Vaccine Era in the Netherlands 1 2 3 2 Charlotte H. Lenselink *, Willem J. G. Melchers , Wim G. V. Quint , Annelies M. J. Hoebers , Jan C. M. 4 1 1 Hendriks , Leon F. A. G. Massuger , Ruud L. M. Bekkers 1 Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands, 2 Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, Nijmegen, the Netherlands, 3 DDL Diagnostic Laboratory, Voorburg, the Netherlands, 4 Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Abstract Background: Infection with Human Papillomavirus (HPV) is a necessary event in the multi-step process of cervical carcinogenesis. Little is known about the natural history of HPV infection among unscreened young adults. As prophylactic vaccines are being developed to prevent specifically HPV 16 and 18 infections, shifts in prevalence in the post vaccine era may be expected. This study provides a unique opportunity to gather baseline data before changes by nationwide vaccination occur. Methods and Principal Findings: This cross-sectional study is part of a large prospective epidemiologic study performed among 2065 unscreened women aged 18 to 29 years. Women returned a self-collected cervico-vaginal specimen and filled out a questionnaire. All HPV DNA-positive samples (by SPF10 DEIA) were genotyped using the INNO-LiPA HPV genotyping assay. HPV point prevalence in this sample was 19%. Low and high risk HPV prevalence was 9.1% and 11.8%, res