shared and distinct functions of the transcription factors irf4 and irf8 in myeloid cell development转录因子irf4的共享和独特的功能和irf8骨髓细胞的发展.pdfVIP

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development 1. 2. 1 1 1 Michio Yamamoto , Takayuki Kato , Chie Hotta , Akira Nishiyama , Daisuke Kurotaki , Masahiro 1 3 1 4 5 Yoshinari , Masamichi Takami , Motohide Ichino , Masatoshi Nakazawa , Toshifumi Matsuyama , 3 2 6 1,2,6 Ryutaro Kamijo , Seiichi Kitagawa , Keiko Ozato , Tomohiko Tamura * 1 Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2 Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan, 3 Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan, 4 Department of Experimental Animal Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 5 Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 6 Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America Abstract Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells. Whilst in myeloid cells IRF8 is known to modulate growth and differentiation, the role of IRF4 is poorly understood. In this study, we show tha