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silk film topography directs collective epithelial cell migration丝绸电影地形指导集体上皮细胞迁移
Silk Film Topography Directs Collective Epithelial Cell
Migration
1. 2. 2
Brian D. Lawrence , Zhi Pan , Mark I. Rosenblatt *
1 Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America, 2 Department of Ophthalmology, Weill Cornell Medical College,
New York, New York, United States of America
Abstract
The following study provides new insight into how surface topography dictates directed collective epithelial cell sheet
growth through the guidance of individual cell movement. Collective cell behavior of migrating human corneal limbal-
epithelial cell sheets were studied on highly biocompatible flat and micro-patterned silk film surfaces. The silk film edge
topography guided the migratory direction of individual cells making up the collective epithelial sheet, which resulted in a
75% increase in total culture elongation. This was due to a 3-fold decrease in cell sheet migration rate efficiency for
movement perpendicular to the topography edge. Individual cell migration direction is preferred in the parallel approach to
the edge topography where localization of cytoskeletal proteins to the topography’s edge region is reduced, which results
in the directed growth of the collective epithelial sheet. Findings indicate customized biomaterial surfaces may be created
to direct both the migration rate and direction of tissue epithelialization.
Citation: Lawrence BD, Pan Z, Rosenblatt MI (2012) Silk Film Topography Directs Collective Epithelial Cell Migration. PLoS ONE 7(11): e50190. doi:10.1371/
journal.pone.0050190
´ `
Editor: Christophe Egles, Universite de Technologie de Compiegne, France
Received July 16, 2012; Accept
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