similar pathogen targets in arabidopsis thaliana and homo sapiens protein networks类似的病原体在拟南芥和智人蛋白质网络的目标.pdfVIP

Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks 1 2 Paulo Shakarian *, J. Kenneth Wickiser 1 Paulo Shakarian Department of Electrical Engineering and Computer Science, United States Military Academy, West Point, New York, United States of America, 2 J. Kenneth Wickiser Department of Life Science, United States Mi litary Academy, West Point, New York, United States of America Abstract We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various ‘‘shells’’ based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power- law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked. Citation: Shakarian P, Wickiser JK (2012) Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks. PLoS ONE 7(9): e45154. doi:10.1371/journal.pone.0045154 Editor: Ying Xu, University of Georgia, United States of America Received April 23, 2012; Accepted August 16, 2012; Published September 21, 2012 This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.