sonic hedgehog gene delivery to the rodent heart promotes angiogenesis via inosnetrin-1pkc pathway音猬因子的基因传递到啮齿动物心脏通过inosnetrin-1pkc途径促进血管生成.pdfVIP

Sonic Hedgehog Gene Delivery to the Rodent Heart Promotes Angiogenesis via iNOS/Netrin-1/PKC Pathway Rafeeq P. H. Ahmed, Khawaja Husnain Haider, Jiang Shujia, Muhammad Rizwan Afzal, Muhammad Ashraf* Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America Abstract Background: We hypothesized that genetic modification of mesenchymal stem cells (MSCs) with Sonic Hedgehog (Shh) transgene, a morphogen during embryonic development and embryonic and adult stem cell growth, improved their survival