spatially-resolved eigenmode decomposition of red blood cells membrane fluctuations questions the role of atp in flickering在固有模式分解红血球膜atp在闪烁的波动问题.pdfVIP

Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering 1 1 1 2 1,3 Daniel Boss *, Annick Hoffmann , Benjamin Rappaz , Christian Depeursinge , Pierre J. Magistretti , Dimitri Van de Ville4,5, Pierre Marquet1,3 ´ ´ ´ ´ 1 Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland, 2 Advanced Photonics Laboratory, Ecole Polytechnique Federale de ´ Lausanne, Lausanne, Vaud, Switzerland, 3 Centre de Neurosciences Psychiatriques, Departement de psychiatrie DP-CHUV, Prilly-Lausanne, Vaud, Switzerland, 4 Institute of ´ ´ Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland, 5 Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland Abstract Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better understanding of these remarkable biomechanical membrane properties altered in some pathological states including blood diseases. In particular the discussion over the thermal or metabolic origin of the CMF has led in the past to a large number of investigations and modeling. However, the origin of the CMF is still debated