厄贝沙坦片说明书（Irbesartan Tablets manual）.docVIP

厄贝沙坦片说明书（Irbesartan Tablets manual） Irbesartan Tablets manual Irbesartan Tablets Name used before： Trade name: English Name: Irbesartan Tablets Chinese Pinyin: Ebeishatan Pian The main ingredient of this product is irbesartan, and its chemical name is 2- butyl -3-[4-[2- (1H-, four azole, -5- base) phenyl] benzyl Basal]-1,3- two, -[4.4], -1-, -4-, allyl ketone. Its structural formula is: [traits] This product is a film coating, white or white after coating. [pharmacology and toxicology] This product is an angiotensin II (Angiotensin II, Ang II) receptor inhibitor that inhibits the transformation of Ang I For Ang II, it can specifically antagonize angiotensin converting enzyme 1 receptor (AT1), which has a great antagonism against AT1 At AT2 8500 times, by selectively blocking the binding of Ang II to the AT1 receptor, it inhibits vasoconstriction and aldehydes The release of ketones produces a hypotensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, and other hormone receptors, nor does it inhibit blood pressure An ion channel that regulates the sodium balance. [pharmacokinetics] According to foreign reports, this product can be absorbed rapidly after oral administration, and the bioavailability is 60 ~ 80%, and it is not eaten Effects of matter. The peak time of plasma was 1 to 1.5 hours, and the half-life was 11~15 hours. Within three days. State. In vitro studies on the use of irbesartan by glucose oxidation or oxidative metabolism showed that cytochrome P450 is mainly composed of cytochrome P450 2C9 oxidation. This product and metabolite are excreted through the biliary tract and kidneys. The plasma protein binding rate of irbesartan was 90%. According to domestic reports, healthy subjects received oral serum 300mg, peaking at about 1.9 hours, The peak concentration is about 4058 g/L, and the elimination phase half-life (t1/2 beta) is about 10.2 hours. [indications] Hypertensive disease. [usage and dosage] Oral: recommended st