22 解热镇痛抗炎药（22 antipyretic, analgesic and anti-inflammatory drugs）.docVIP

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22 解热镇痛抗炎药（22 antipyretic, analgesic and anti-inflammatory drugs）.doc

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22 解热镇痛抗炎药（22 antipyretic, analgesic and anti-inflammatory drugs）

22 解热镇痛抗炎药（22 antipyretic, analgesic and anti-inflammatory drugs） The twentieth chapter is antipyretic, analgesic and anti-inflammatory drugs Antipyretic, analgesic and anti-inflammatory drugs (antipyretic-analgesic, and, antiinflammatory, agents) are a type of antipyretic, analgesic, and most anti-inflammatory and antirheumatic drugs. The chemical structure and anti-inflammatory mechanism are different from those of steroid hormones, so they are also called nonsteroidal anti-inflammatory drugs (nonsteroidal, antiinflammatory, drugs, NSAIDS). According to the chemical structure, can be divided into salicylic acid, aniline, pyrazole ketone and organic acids four kinds. The pharmacological action and the mechanism of action of these drugs are basically the same. I. The basic function and mechanism of antipyretic, analgesic and anti-inflammatory drugs 1. antipyretic action to reduce fever body temperature, and no effect on normal body temperature. Inhibition of central PG synthase (cyclo oxygenase) reduces PG synthesis, increases abnormally elevated body temperature regulation points, and increases heat dissipation, such as cutaneous vasodilation, increased sweating, and hence fever. 2. the analgesic effect has the analgesic effect of moderate, chronic pain especially good inflammatory pain, headache, toothache, commonly used in clinical nerve pain, muscle and joint pain and menstrual pain, with no long addictive and ineffective for severe traumatic pain and visceral smooth muscle cramps. The main site of action is in the peripheral nervous system. Inhibition of local PG synthesis in inflammation plays a role in analgesia, and can not rule out some of the analgesic effects through the central nervous system. 3., anti-inflammatory, anti rheumatic effect, this class of drugs in addition to acetaminophen, have significant inhibition of inflammatory exudate, reduce redness, swelling, heat and pain of anti-inflammatory, anti rheumatic effect. It is mainly used to control th