IL-6在子宫内膜异位症患者血清及腹腔液中变化.docVIP

IL-6在子宫内膜异位症患者血清及腹腔液中变化 　【摘要】 目的 检测子宫内膜异位症（EM） 患者与正常妇女血清及腹腔液中IL-6的水平, 探讨其与子宫内膜异位症发病的关系。方法 子宫内膜异位症患者52例作为研究组（选择的是子宫内膜异位症病人，非正常妇女），正常妇女45例作为对照组, 采用双抗体夹心酶联免疫吸附技术 （Sandwich ELISA） 检测两组妇女血清及腹腔液中IL-6水平。结果 血清IL-6水平两组分别为: EM组207±76pg/ml,正常妇女组148±56pg/ml, 两组间比较差异有非常显著性（Plt;0.01） 。腹腔液IL-6水平两组分别为:EM组292±98pg/ml, 正常妇女组164±65pg/ml, 两组间比较差异亦有非常显著性（Plt;0.01） 。相关性分析发现: EMT组血清与腹腔液IL-6呈正相关（r=0.471,P=0.002）, 正常妇女组血清与腹腔液IL-6无明显相关性。结论 EMT患者血清与腹腔液IL-6水平较对照组均显著增高,IL-6可能是EM发生的关键因子之一。 【关键词】 子宫内膜异位症 IL-6（白介素－6） 血清 腹腔液 【Abstract】 Objective To investigate the levels of （IL-6） in serum and peritonaeal fluid of to endometriosis （ EM） patients and healthy women and approach the relation of IL-6 and EM.Methods Levels of IL-6 in serum and peritonaeal fluid in abdominal cavity fluid were determined detected by a solid quantitative sandwich enzyme immunoassay technique （ Sandwich（Sandwich ELISA） both in EM group and in control groupss, and. The relationship of IL-6 levels in serum and in abdominal cavity peritonaeal fluid fluid were analyzed1Resultsanalyzed.Results Serum concentrations of IL-6 were increased （Plt;0.01） in EM group （ 207±76） pg/ml than that of in control group s（148±56） pg/ml.Concentrations of MCP - 1 in peritonaealabdominal cavity fluid were increased（Plt;0.01） in EM group （292±98） pg/ml than that in controls control group （164±65） pg/ml 1ml. In EM group, nonparametric correlations analysis demonstrated that concentrations of serum IL-6 were positively correlated with those in peritonaealabdominal cavity fluid （r=0.471,P=0.002） , but such a correlation did not be found in controls.Conclusion Serum levels of IL-6 in EM increase significantly and higher concentrations of MCP - 1 may be partly responsible for EM in a specialway specialway. 【Key words】 Eendometriosis;IL-6;Serumserum;peritoneal fluid Abdominal cavity fluid 子宫内膜异位症（EMT） 是妇产科常见病, 在育龄妇女中占3%～10%。在行输卵管结扎术的妇女中, 无症状的EMs 占1%～7%。原发性不孕妇女中EMs 占9%～50%。研究表明EMT 发病率有种族差异, 非洲妇女低于东亚妇女。许多研究者认为EMT的发生与免疫系统的改变有关, 细胞免疫和体液免疫的改变都与该病的发展密切相关。本