中药内服配合艾灸对椎动脉型颈椎病患者血浆内皮素及降钙素基因相.docVIP

中药内服配合艾灸对椎动脉型颈椎病患者血浆内皮素及降钙素基因相 　【摘要】 　　目的观察口服补阳还五汤配合艾灸百会、大椎对椎动脉型颈椎病患者血浆内皮素（ET）、降钙素基因相关肽（CGRP）含量的影响。方法将78例椎动脉型颈椎病患者随机分为两组。观察组40例，采用口服补阳还五汤配合艾灸百会、大椎治疗；对照组38例，采用复方丹参注射液静脉滴注加口服西比灵治疗。结果治疗后两组血浆ET含量均呈下降趋势，CGRP含量均呈上升趋势。观察组ET明显下降，CGRP明显上升，且接近正常值水平，与治疗前比较，有极显著差异（Plt;0.01），与对照组比较，有显著性差异（Plt;0.05）。结论 口服补阳还五汤配合艾灸百会、大椎能显著调节椎动脉型颈椎病患者血浆ET，CGRP含量，抑制缩血管物质的释放，促进舒血管物质的释放，从而缓解椎动脉痉挛，改善脑部供血情况。 【关键词】 椎动脉型颈椎病 补阳还五汤 艾灸 血浆内皮素 降钙素基因相关肽 　　Abstract：ObjectiveTo observe the effect of traditional Chinese medicine for oral use and Moxikustion on the econtents of ET and CGRP in blood plasm of vertebral artery type of cervical spondylosis patients.Methods78 patients were divided into 2 groups randomly, they were observation group (40 patients) and control group (38 patients). Patients in observation group were treated with Buyang Huanwu decoction for oral use and moxibustion in Baihui and Dazhui points. Patients in control group were treated with compound recipe Danshen injection for intravenous drip and Flunarizine for oral use. ResultsAfter treated, the content of ET in blood plasm in both groups was declined, while the content of CGRP increased. But the content of ET in observation group declined obviously and the content of CGRP rose significantl and reached to the normal one. Compared with pretherapy, there was obviously significant difference (Plt;0.01). Compared with control group, there was significant difference (Plt;0.05).ConclusionThis treatment on vertebral artery type of cervical spondylosis patients can obviously regucate the contents of ET and CGRP, restrain release of vasoconstrictor material and promote release of vasodialtor material alleviate vertebral artery spasm and improve encephalica blood-supply. 　　Key words：Vertebral artery type of cervical spondylosis ; Buyang Huanwu decoction; Moxibustion； ET； CGRP 　　椎动脉型颈椎病是中老年人的常见病、多发病，其发病率正逐年上升，近年来又有患病年龄逐步降低趋势。笔者采用口服补阳还五汤配合艾灸百会、大椎治疗椎动脉型颈椎病，观察了患者治疗前后血浆内皮素（ET）、降钙素基因相关肽（CGRP）含量的变化。现报道如下。 　　1 临床资料 　　1.1 诊断标准 参照国家中医药管理局颁布的《中医病症诊断疗效标准》［1］及1