二甲双胍格列吡嗪复合制剂治疗老年2型糖尿病临床疗效观察.docVIP

二甲双胍格列吡嗪复合制剂治疗老年2型糖尿病临床疗效观察 【摘要】 目的 探讨二甲双胍格列吡嗪复合制剂治疗老年2型糖尿病疗效及安全性。方法 38例年龄gt;60岁且糖尿病病程gt;5年的老年2型糖尿病患者随机分为治疗组和对照组， 各19例。治疗组给予二甲双胍格列吡嗪复合制剂， 对照组单纯给予二甲双胍治疗。比较两组临床疗效。结果 治疗3、6个月， 治疗组空腹血糖（FPG）、餐后2 h血糖（2 h PG）及糖化血红蛋白（HbA1c） 均低于对照组， 差异有统计学意义（Plt;0.05）；治疗组不良反应发生率为15.79%低于对照组的26.32%， 但差异无统计学意义（Pgt;0.05）。两组患者不良反应为轻度腹胀不适反应， 未予停药， 腹胀可耐受。治疗组治疗总有效率为94.74% 高于对照组的68.42%， 差异具有统计学意义（Plt;0.05）。结论 二甲双胍格列吡嗪复合制剂是治疗老年2型糖尿病的理想治疗药物。　　【关键词】 老年2型糖尿病；二甲双胍格列吡嗪复合制剂　　DOI：10.14163/j.cnki.11-5547/r.2017.05.039　　Observation on clinical effect of metformin-glipizide compound preparation in the treatment of 38 cases of elderly type 2 diabetes mellitus YU Zhen-xia. Beijing City Daxing District Huangcun Hospital， Beijing 102600， China　　【Abstract】 Objective To explore the curative effect and security of metformin-glipizide compound preparation in the treatment of elderly type 2 diabetes mellitus. Methods 38 elderly type 2 diabetes mellitus patients with age gt; 60 years old and diabetes duration gt; 5 years were randomly divided into treatment group and control group， with 19 cases in each group. The treatment group received metformin-glipizide compound preparation， and the control group received metformin treatment. Clinical curative effect was compared in two groups. Results After 3 and 6 months of treatment， the treatment group had lower fasting plasma glucose （FPG）， 2 h postprandial blood glucose （2 h PG） and glycosylated hemoglobin （HbA1c） than the control group， and the difference had statistical significance （Plt;0.05）. The treatment group had lower incidence of adverse reactions as 15.79% than 26.32% in the control group， but the difference had no statistical significance （Pgt;0.05）. Both groups had adverse reactions of mild abdominal distension reaction， and could be tolerated without drug withdrawal. The treatment group had higher total treatment effective rate as 94.74% than 68.42% in the control group， and the difference had statistical significance （Plt;0.05）. Conclusion Metformin-glipizide co