灯盏花素治疗慢性阻塞性肺疾病急性加重期合并低氧血症疗效观察.docVIP

灯盏花素治疗慢性阻塞性肺疾病急性加重期合并低氧血症疗效观察 　 作者：陈菊屏，熊瑛，李国平，周宁 【摘要】 　　目的观察灯盏花素对慢性阻塞性肺疾病急性加重期(AECOPD)合并低氧血症的疗效。方法60例入院治疗的AECOPD合并低氧血症的患者随机分为两组，均以常规治疗，Ⅰ组加用灯盏花素，观察血白细胞数（WBC）、中性粒细胞率（N）、血沉(ERS)、C-反应蛋白(CRP)、1秒率（FEV1%）、1秒量与用力呼气容积的比值（FEV1/FVC）、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、凝血酶原时间（PT）、住院时间（HT）等指标。结果治疗后两组均有改善（Plt;0.05），Ⅰ组较Ⅱ组之血WBC，N，ERS，CRP，FEV1%，FEV1/FVC，PaO2，PaCO2，PT，HT等均改善明显（Plt;0.05）。结论加用灯盏花素可能增加对AECOPD合并低氧血症的患者抗炎作用，改善其通气功能，减轻其血液高凝状态。 【关键词】 灯盏花素 慢性阻塞性肺疾病急性加重期 低氧血症 　　Abstract：ObjectiveTo observe the curative effect of breviscapine on acute exacerbation of chronic obstructive pulmonary disease with hypoxemia. Methods60 AECOPD patients with hypoxemia that needed hospitalization cure were divided into two groups at random, and were given the routine cure , 30 patients in groupⅠ were given breviscapine. The quantity of leukocyte in peripheral blood (WBC)，the quotient of the quantity of neutrophil to leukocyte in peripheral blood（N），the erythrocyte sedimentation rate (ESR), the serum levels of C-reaction protein (CRP), the arterial partial pressure of oxygen(PaO2), the arterial partial pressure of carbon dioxide (PaCO2),the percent of forced expiratory volum in one second (FEV1%),the quotient of forced expiratory volum in one second to forced vital capacity(FEV1/FVC), the prothrombin time (PT) and the hospitalization’time(HT) were observed. ResultsAfter treatment, the indexes were improved in the two groups（plt;0.05）, and the effects were obviously more compared with groupⅡ on WBC, N, ESR, CRP, FEV1%, FEV1/FVC, PaO2, PaCO2, PT and HT.ConclusionBreviscapine can enhance anti-inflammatory activities, inprove pulmonary ventilation function, and lighten hypercoagulability in AECOPD patients with hypoxemia. 　　Key words：Breviscapine； Acute exacerbation of chronic obstructive pulmonary disease； Hypoxemia 　　慢性阻塞性肺疾病急性加重期(AECOPD)合并低氧血症的治疗仍在不断探索与完善中［1］，祖国医学对其的治疗积累了丰富的经验，其中灯盏花素所具有的独特功效引人注目［2］。灯盏花又名灯盏细辛、短茎飞蓬等，为菊科植物短葶飞蓬，以全草或根入药， 性味辛、微苦、温，具有活血化淤、散寒祛湿、祛风解毒、舒筋通络、散寒解表的功效［3］。灯盏花素注射液是灯盏花乙醇提取物的水溶液，主要含灯盏乙素、少量灯盏甲