胰复敏胶囊治疗2型糖尿病胰岛素抵抗临床探究.docVIP

胰复敏胶囊治疗2型糖尿病胰岛素抵抗临床探究 　 作者：郭俊杰,吕蕾,刘亚丽,郭鹏云,刘照峰,赵玉立,徐秀峰 【摘要】 目的 探讨胰复敏胶囊治疗2型糖尿病胰岛素抵抗的临床疗效及对相关指标的影响。方法 将符合2型糖尿病胰岛素抵抗诊断标准同时又符合气阴两虚、痰瘀毒互结证中医辨证标准者240例随机分为对照组和治疗组,每组120例。治疗组给予胰复敏胶囊,对照组口服盐酸吡格列酮,疗程12周。观察2组患者临床症状及血糖、血脂、C反应蛋白(CRP)、胰岛素敏感指数(ISI)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)及肝、肾功能的变化。结果 治疗组治疗后中医症状、体征均明显改善。治疗组总有效率为88.1%,对照组总有效率为52.9%,治疗组疗效明显优于对照组。2组患者治疗后HOMA-IR、FINS均显著下降,ISI明显升高,空腹血糖、餐后2 h血糖、糖化血红蛋白均明显下降；2组治疗后三酰甘油、低密度脂蛋白胆固醇均有下降,治疗组总脂固醇、CRP显著下降,与对照组比较,差异有统计学意义。结论 胰复敏胶囊能改善2型糖尿病患者胰岛素抵抗。 【关键词】 胰复敏胶囊；2型糖尿病；胰岛素抵抗；C反应蛋白 　　Abstract：Objective To study the clinical therapeutic effect of Yifumin Capsule in treating type 2 diabetic insulin resistance and its effect on relevance indexes. Methods Two hundred and forty cases of type 2 diabetic insulin resistance with deficiency of qi-yin and stagnation of phlegm and toxin were divided randomly into two groups, 120 cases in each group. The treatment group was given orally Yifumin Capsule, and the control group was given orally pioglitazone. The treatment course of the two groups was 12 weeks. Clinical symptoms, blood glucose, blood lipid, CRP, ISI, FINS, HOMA-IR, liver and kidney function were detected respectively. Results Chinese medicine symptoms and signs were all improved. The total effective rate of clinical effect was 88.1% in treatment group and 52.9% in control group. The clinical therapeutic effect of the treatment group was obviously better than the control group. Both groups had a notable seducement in HOMA-IR, FINS, FPG, 2 h PG, HbA1c, TG and LDL-C with an obviously improvement in ISI after the treatment. Compared with the control group, the treatment group had a significant decrease in TC and CRP with notable difference. Conclusion Yifumin Capsule can effectively improve the insulin resistance of type 2 diabetic patients. 　　Key words：Yifumin Capsule；type 2 diabetes mellitus；insulin resistance；C-reactive protein 　　 　　胰岛素抵抗(Insulin Resistance,IR)是指胰岛素执行其正常生物作用的效应不足,表现为外周组织尤其是肌肉、脂肪组织对葡萄糖的利用障碍。IR既是2型糖尿病的主要发病机制,贯穿于