a novel approach to simultaneously scan genes at fragile sites一种新颖的方式同时扫描基因在脆弱的网站.pdfVIP

BMC Cancer BioMed Central Technical advance Open Access A novel approach to simultaneously scan genes at fragile sites 1 1 2 Pascale Willem* , Jacqueline Brown and Jan Schouten Address: 1Department of Hematology and Molecular Medicine University of the Witwatersrand and the National Health Laboratory Services, WITS Medical School, 8 York road, 2 193 Parktown, South Africa and 2MRC Holland, Hudsonstraat, Amsterdam, The Netherlands Email: Pascale Willem* - pascale.willem@nhls.co.za; Jacqueline Brown - jacqueline.brown@nhls.ac.za; Jan Schouten - schouten@mrc- * Corresponding author Published: 08 August 2006 Received: 23 March 2006 Accepted: 08 August 2006 BMC Cancer 2006, 6:205 doi:10.1186/1471-2407-6-205 This article is available from: /1471-2407/6/205 © 2006 Willem et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Fragile sites are regions of the genome sensitive to replication stress and to exposure to environmental carcinogens. The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively. There is growing evidence that both genes cont