a novel approach to the clustering of microarray data via nonparametric density estimation一种新颖的微阵列数据的聚类方法通过非参数密度估计.pdfVIP

De Bin and Risso BMC Bioinformatics 2011, 12:49 /1471-2105/12/49 METHODOLOGY ARTICLE Open Access A novel approach to the clustering of microarray data via nonparametric density estimation * Riccardo De Bin, Davide Risso Abstract Background: Cluster analysis is a crucial tool in several biological and medical studies dealing with microarray data. Such studies pose challenging statistical problems due to dimensionality issues, since the number of variables can be much higher than the number of observations. Results: Here, we present a general framework to deal with the clustering of microarray data, based on a three-step procedure: (i) gene filtering; (ii) dimensionality reduction; (iii) clustering of observations in the reduced space. Via a nonparametric model-based clustering approach we obtain promising results both in simulated and real data. Conclusions: The proposed algorithm is a simple and effective tool for the clustering of microarray data, in an unsupervised setting. Background scheme accounts for gene selection through mixtures of t The analysis of gene expression microarray data using distributions, and dimensionality reduction through a clustering techniques plays an important role, for mixture of factor analyzers. More precisely, they select a instance, in the discovery, validation, and understanding gene on the basis of a likelihood ratio statistic for testing of various classes and subclasses of cancer [1]. There are one versus two components in the mixture model. In the two ways of clustering a gene expression matrix [2,3]: second step of their algorithm, they cluster the samples (i) gene function may be inferred from clu