原创力文档a phase i study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates一个阶段我学习的日常治疗新生儿ceramide-dominant三脂质混合物开始.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a phase i study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates一个阶段我学习的日常治疗新生儿ceramide-dominant三脂质混合物开始
Lowe et al. BMC Dermatology 2012, 12:3
/1471-5945/12/3
RESEARCH ARTICLE Open Access
A phase I study of daily treatment with a
ceramide-dominant triple lipid mixture
commencing in neonates
1,2* 1,2,3 1,2 3 4,5 1,2
Adrian J Lowe , Mimi LK Tang , Shyamali C Dharmage , George Varigos , Della Forster , Lyle C Gurrin ,
1,2,3 6 1 2,3,6
Colin F Robertson , Michael J Abramson , Katrina J Allen and John Su
Abstract
Background: Defects in skin barrier function are associated with an increase risk of eczema and atopic
sensitisation. Ceramide-dominant triple lipid mixture may improve and maintain the infant skin barrier function,
and if shown to be safe and feasible, may therefore offer an effective approach to reduce the incidence of eczema
and subsequent atopic sensitisation. We sort to assess the safety and compliance with daily application of a
ceramide-dominant triple lipid formula (EpiCeram™) commencing in the neonatal period for the prevention of
eczema.
Methods: Ten infants (0-4 weeks of age) with a family history of allergic disease were recruited into an open-label,
phase one trial of daily application of EpiCeram™ for six weeks. The primary outcomes were rate of compliance
and adverse events. Data on development of eczema, and physiological properties of the skin (transepidermal
water loss, hydration, and surface pH) were also measured.
Results: Eighty percent (8/10) of mothers applied the study cream on 80% or more of days during the six week
intervention period. Though a number of adverse events unrelated to study product were reported, there were no
adverse skin reactions
您可能关注的文档
- a new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns一种新的实验方法研究细菌的基因组岛进化识别岛与细菌的寄主专一性的基因表达模式.pdf
- a new analysis tool for individual-level allele frequency for genomic studies一个新的分析工具对个人层面基因组研究等位基因频率.pdf
- a new enzymatic route for production of long 5'-phosphorylated oligonucleotides using suicide cassettes and rolling circle dna synthesis新的生产长5 '磷酸化酶途径使用自杀式磁带和滚动循环dna合成寡核苷酸.pdf
- a new implementation of high-throughput five-dimensional clone pooling strategy for bac library screening一个新的实现高通量的五维的bac克隆池策略库筛选.pdf
- a new generation of pprig-based retroviral vectors新一代的pprig-based逆转录病毒载体.pdf
- a new implicit review instrument for measuring quality of care delivered to pediatric patients in the emergency department一个新的隐式检查的护理质量测量仪送到急诊儿科患者.pdf
- a new mapping method for quantitative trait loci of silkworm一个新的映射蚕数量性状的方法.pdf
- a new 2d-based method for myocardial velocity strain and strain rate quantification in a normal adult and paediatric population assessment of reference values一个新的2 d - base速度心肌应变和应变率量化方法在一个正常成人和儿科人口评估的参考价值.pdf
- a new measurement of sequence conservation一个新的测量序列的保护.pdf
- a new method for determination of varicella-zoster virus immunoglobulin g avidity in serum and cerebrospinal fluid水痘一带状疱疹病毒免疫球蛋白g的一种新方法测定血清和脑脊液的热望.pdf
- a philosophical analysis of the evidence-based medicine debate循证医学的哲学分析讨论.pdf
- a phylogenomic gene cluster resource the phylogenetically inferred groups (phigs) databasephylogenomic基因集群资源系统推断组(phigs)数据库.pdf
- a phylogenomic analysis of the actinomycetales mce operonsu201d的phylogenomic分析放线菌目mce操纵子.pdf
- a phylogenetic mosaic plastid proteome and unusual plastid-targeting signals in the green-colored dinoflagellate lepidodinium chlorophorum系统发育马赛克质体蛋白质组和不寻常的plastid-targeting信号才腰鞭毛虫lepidodinium chlorophorum.pdf
- a phylogenomic profile of hemerythrins, the nonheme diiron binding respiratory proteins蚯蚓血红蛋白phylogenomic概要,nonheme diiron绑定呼吸蛋白.pdf
- a phylogenomic profile of globins球蛋白的phylogenomic概要文件.pdf
- a phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on egfr mediated ap-1 expression and cancer cell proliferation磷酸化有缺陷的视黄酸受体突变体模拟的影响视黄酸对egfr介导ap-1表达式和癌症细胞增殖.pdf
- a phenanthrene derived parp inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells菲派生parp抑制剂是一种extra-centrosomes分块独家代理根除人类癌症细胞.pdf
- a pilot randomised controlled trial of the feasibility of using body scan and isometric exercises for reducing urge to smoke in a smoking cessation clinic飞行员使用身体扫描的可行性的随机对照试验和静力锻炼减少冲动烟戒烟诊所.pdf
- a physical map of the papaya genome with integrated genetic map and genome sequence的木瓜基因组物理图谱综合遗传图谱和基因组序列.pdf
文档评论（0）